试样薄化导致的Cu－Al贝氏体／马氏体组织变化

加热到１１７３Ｋ的Ｃｕ－２５ａｔ；％Ａｌ合金块状试样经７２３Ｋ６０Ｓ等温淬火后其组织由片状的“羽毛状贝氏体（９Ｒ结构）和β＿１＇马氏体（１８Ｒ结构）组成。当试样被离子束轰去进一步薄化后，在足够薄的区域内生成了许多２Ｈ结构的薄片马氏体。初步分析认为该薄片马氏体形成的原因是由于贝氏体生成时在试样内留下了高的应力场，当试样薄化到一临界厚度以下时，试样区的三维约束条件松弛使试样内的应力场触发了薄片马氏体的生成。这些薄片马氏体是通过位于贝氏体界面上位错的重新启动而长大的。     

Hybrid verrucous squamous cell carcinoma of sinonasal tract: a case report

Verrucous carcinoma is a variant of squamous cell carcinoma and should be distinguished from benign papilloma and well-differentiated nonverrucous squamous cell carcinoma. It is rare tumor of the sinonasal tract. Occasionally, conventional squamous cell carcinomatous components may be seen in verrucous carcinoma. This entity is called a hybrid verrucous squamous cell carcinoma. We report a case of hybrid verrucous squamous cell carcinoma occurring in the nasal cavity and paranasal sinus of a 67-year-old male. The removed mass shows the typical feature of verrucous carcinoma, but focally conventional squamous cell carcinomatous area is also noted. The treatment of this case follows verrucous carcinoma, but close follow up is mandatory because it may potentially spread to regional lymph nodes in contrast to pure form of verrucous carcinoma.     

The effect of silica characterization on the microstructure of BaFe12O19 ferrites

The anisotropically formed BaFe₁₂O₁₉ ferrites were prepared from the hot-rolled mill scale and silica was added to the ferrite during fine milling in the range 0.15 to 0.50 wt%. These ferrites were sintered at 1220° C for 2 h. The grain growth of the ferrites is dominantly influenced by the sizes of the silica added. Coarse-grain ( 1m) silica tends to promote discontinuous grain growth, which increases drastically with slightly increasing amounts of silica added, while fine-grain ( 0.013m) silica tends to retain fine grain microstructures with the same increasing amount of silica. The average grain size of the ferrite without silica addition was 8 to 10m. The size was increased to as large as 30m on addition of 0.15% coarse-grain silica and the microstructure was full of extremely large grains on the addition of 0.50% coarse-grain silica.     

Intelligent copyright protection system using a matching video retrieval algorithm

Many video service sites headed by YouTube know what content requires copyright protection. However, they lack a copyright protection system that automatically distinguishes whether uploaded videos contain legal or illegal content. Existing protection techniques use content-based retrieval methods that compare the features of video. However, if the video encoding has changed in resolution, bit-rate or codec, these techniques do not perform well. Thus, this paper proposes a novel video matching algorithm even if the type of encoding has changed. We also suggest an intelligent copyright protection system using the proposed algorithm. This can serve to automatically prevent the uploading of illegal content. The proposed method has represented the accuracy of 97% with searching algorithm in video-matching experiments and 98.62% with automation algorithm in copyright-protection experiments. Therefore, this system could form a core technology that identifies illegal content and automatically excludes access to illegal content by many video service sites.     

Laser glazing of an Fe-C-Sn alloy

Morphology and geometry of melted zones, cooling rates, microstructure and microhardness in the laser-glazed Fe-4%C-10%Sn alloy have been investigated. The computer simulation on the basis of the moving gaussian source model was used successfully to predict the maximum width and depth of the melted zone and the cooling rate. The microstructure from the surface to the bottom of the laser-melted zone is a non-crystalline phase, dendritic grains and a microcrystalline zone successively. Values of the averaged-spacing of the non-crystalline phase are 0.205⁶ and 0.121⁹nm, respectively; twinned martensites, having an axial ratioc/a of 1.128, existed in dendritic grains, and carbides of Fe₃ C at the interdendritic regions; the microcrystalline zone was composed of -Fe and a new bet (a=0.415 nm,c=0.955 nm) phase. The different microstructure in the melted zone can be explained by the results of the heat flow calculation. A fine eutectic structure (-Fe + Fe₃C) was observed in heat-affected zones. Microhardness of the eutectic structure can be predicted by the empirical relation of fracture stress to the interlamellar spacing of pearlite.     

Particular behavior of spindle thermal deformation by thermal bending

Thermally induced errors reduce the accuracy in precision machining, and a great deal of research has been presented on compensation for these errors in machine tools. However, during the transition period after commencing or stopping spindle rotation, thermal deformation behavior is very complex. In particular, the y-directional movement of the vertical machining center cannot be explained by thermal expansion alone because of the relationship between deformation and temperature. Thermal bending that is generated from the thermal gradient in the structure causes this movement. In the research described in this paper, a theoretical explanation and an experimental verification is given for the particular behavior of spindle thermal deformation. As it is not easy to map the relationship of the compensation model, separation of the steady from the non-steady state in the mapping process is strongly recommended.     

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A.     

An Autophagy-Disrupting Small Molecule Promotes Cancer Cell Death via Caspase Activation

A novel autophagy inhibitor, autophazole (Atz), which promoted cancer cell death via caspase activation, is described. This compound was identified from cell-based high-content screening of an imidazole library. The results showed that Atz was internalized into lysosomes of cells where it induced lysosomal membrane permeabilization (LMP). This process generated nonfunctional autolysosomes, thereby inhibiting autophagy. In addition, Atz was found to promote LMP-mediated apoptosis. Specifically, LMP induced by Atz caused release of cathepsins from lysosomes into the cytosol. Cathepsins in the cytosol cleaved Bid to generate tBid, which subsequently activated Bax to induce mitochondrial outer membrane permeabilization (MOMP). This event led to cancer cell death via caspase activation. Overall, the findings suggest that Atz will serve as a new chemical probe in efforts aimed at gaining a better understanding of the autophagic process.